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Application Areas
- Biology and drug discovery: vectorology as an experimental tool
- Cancer immunotherapy: in vivo RNA immune programming
- Precision gene therapy: transient RNA delivery of genome editors
- Regenerative beauty: transient RNA programming for healthy skin
- Regenerative dermatology: topical mRNA delivery to the skin
- RNA vaccination: programmable antigen delivery with RNA-ONE
Lentiviral vectors
- Extra QC
- Lenti Flpo
- Lenti-ONE ANCH-OR-GFP
- Lenti-ONE AOX
- Lenti-ONE Bcl2
- Lenti-ONE BDNF
- Lenti-ONE Cas9
- Lenti-ONE Cas9-GFP
- Lenti-ONE Cas9-gRNA
- Lenti-ONE ChR2-GFP
- Lenti-ONE CNTF
- Lenti-ONE Cre-NLS
- Lenti-ONE eNpHR3-GFP
- Lenti-ONE GDNF
- Lenti-ONE GFP
- Lenti-ONE GFP-Luc
- Lenti-ONE GPX
- Lenti-ONE gRNA
- Lenti-ONE GUCY2D
- Lenti-ONE Luc
- Lenti-ONE MyoD
- Lenti-ONE Neo
- Lenti-ONE PhiC31-NLS
- Lenti-ONE RFP
- Lenti-ONE RFP-Luc
- Lenti-ONE shRNA
- Lenti-ONE SOD
- Lenti-ONE VEGF121
- Lenti-ONE VEGF165a
- Lenti-ONE VEGF165b
- Ready-to-use vectors
Knowledge
- Choose the right Pol-II promoter for your lentiviral vector
- Easy and efficient generation of clonal cell lines using Lenti-ONE
- FAQ
- Generate KO with Zinc Finder Nucleases
- Kinetics of expression of different types of lentiviral vectors
- Lentiviral Vectors
- Lentiviral vectors: a powerful tool with a wide range of applications
- Lentivirus Transduction - Lentivirus Infection Protocol
- Literature - Selection of Publications
- News
- On-Demand Services
- Protocols
- Safety & Regulatory
- Transduce cells with highly transient lentiviral vectors
- Transduction with integrase-deficient lentiviral vectors
- Vector Options
Company
Blog
- Blog
- ‘It’s a vote for hope’: first gene therapy for muscular dystrophy nears approval, but will it work? - Nature
- ‘Smart’ antibiotic can kill deadly bacteria while sparing the microbiome - Nature
- A new study reveals unintended CRISPR/Cas9 editing events
- A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion | Nature Nanotechnology
- Alternative oxidase (AOX)
- Antibiotic use, certain gut bacteria affect CAR-T efficacy, toxicity
- Appetite for Destruction: The Indiscriminate Nuclease Activity of Cas12a2
- Australian Vaccine First In World To Show Ability To Totally Block Covid-19 Virus Transmission
- Barcoding small extracellular vesicles with new CRISPR-based system
- Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells | Nature Biotechnology
- Bispecific LV20.19 CAR T Cells Induce 92% CR Rate in Relapsed/Refractory Mantle Cell Lymphoma
- BiTEs, CAR T-Cell Therapy, and ADCs Offer Variety of Lymphoma Treatment Options, But Questions Remain
- Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy
- Boosting CAR T cell survival to improve solid tumor therapy
- Breakthrough immunotherapy targets non-cancer cells to prevent breast cancer spread
- Cancer Cells Deliver CRISPR to Fight Cancer
- Cancer treatments boosted by immune-cell hacking - Nature
- Cancer-fighting CAR T cells show promising results for hard-to-treat tumours
- Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment
- CAR T cell therapy may enhance the effectiveness of surgery for solid tumors
- CAR T-Cell Therapy Carves Out a Role in Multiple Myeloma
- CAR T-Cell Therapy Proves Effective in First Trial in Patients with Resistant Multiple Myeloma
- CAR-T cell therapy remains viable for patients in lymphoma remission, study finds
- CAR-T-cell Shows Promise in Patients With Lymphoma of the Brain and Spinal Cord in Early Trial
- Case study highlights Parkinson’s-like toxicity after BCMA-directed CAR T-cell therapy
- CD5 knockout using CRISPR boosts CAR T cell therapy efficacy
- Cellular immunotherapy offers hope for solid tumors
- Clinical Update: TALEN-Edited CAR T-Cell Therapy for Large B-Cell Lymphoma
- Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics | Nature Neuroscience
- Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer
- CRISPR activation and interference screens decode stimulation responses in primary human T cells - Science
- CRISPR screening unveils ATXN3 as a new cancer treatment target
- CRISPR-Based Anti-CD19 CAR T-Cell Therapy Is Safe and Effective in Relapsed/Refractory NHL
- CRISPR-based therapy shows promise for reducing hereditary angioedema attacks
- CRISPR-Mediated Correction of ABCA4 Mutations in Stem Cells May Provide Treatment for Incurable Inherited Disease Causing Vision Loss
- CRISPR/Cas9 deletions induce adverse on-target genomic effects
- CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context | Nature Communications
- Decade-long leukaemia remissions with persistence of CD4+ CAR T cells - Nature
- Delivering the next generation of cancer immunotherapies with RNA - Cell
- Design of T Cell Circuits that Sense Antigen Density to Treat Solid Tumors
- Dual-target CAR-T ‘very promising’ for advanced multiple myeloma
- EchoBack CAR T-cells could be a game changer in cancer immunotherapy
- Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis | Nature Biotechnology
- FDA approves earlier use of Carvykti CAR-T for multiple myeloma
- FDA grants fast track designation to CD33-directed CAR-T for acute myeloid leukemia
- First CAR-T therapy to target BCMA gets FDA nod - Nature
- Gamma delta T cells engineered to be more potent and long-lasting against cancer
- Gene therapy’s comeback: how scientists are trying to make it safer - Nature
- Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse
- Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations
- Human ACE2 Peptide-Mimics Block SARS-CoV-2 Pulmonary Cells Infection - Nature Communication
- Ide-Cel Demonstrates Durable Responses in Relapsed/Refractory Multiple Myeloma
- Improving CAR-based-immunotherapies using a molecular anchor
- Innovative CAR T cell therapy shows promise for relapsed CIDP patients
- Innovative CAR-T cells effectively target glioblastoma with reduced toxicity
- Innovative immunotherapy harnesses natural killer T cells to combat solid tumors
- Liquid biopsy predicts response to CAR-T for multiple myeloma
- MaxCyte signs strategic platform license with LG Chem to advance its allogeneic CAR-T programs
- Metabolically armored CAR-T cells demonstrate lasting efficacy against solid tumors
- Miniaturized CRISPR protein opens door for gene therapy with adeno-associated virus
- Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma
- mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy | Nature Communications
- mRNA-Based CAR T-Cell Therapy Descartes-11 Moves Into Phase 2 Trial in Myeloma
- Nasal Spray Sends CRISPR to the Brain
- Natural killer cells lead the charge in cancer treatment innovation
- New approach reinvigorates exhausted T cells to improve tumor control
- New approach to CAR T cell therapy may extend treatment effectiveness
- New approach to immunotherapy provokes a robust anti-tumor immune response in preclinical models for solid tumors
- New CAR T cell therapy approach minimizes severe side effects
- New discovery on Covid-19
- New DNA recombination toolbox surpasses CRISPR for genome engineering
- New findings could make off-the-shelf CAR T cell therapy a reality
- New gene modification enhances CAR-T cell effectiveness against cancer
- New immunotherapy targets leukemia at its root
- New platform mimics immune interactions to boost cancer treatment
- New project aims to improve the efficacy and safety of CAR T therapies for solid tumors
- New study warns of dangers of gene editing in human embryos
- New supercharged CAR-T cell therapy shows promise against resistant cancers
- New therapeutic target could boost CAR T-cell therapy success in solid tumors
- New type of immunotherapy effective in mice with ovarian cancer
- NICER: A safer alternative to CRISPR/Cas9 for gene editing
- NK cells' role in cancer therapy resistance unveiled
- Nonviral CAR-T is ‘remarkably safe’ and clinically active in B-cell ALL
- Novel approach may prevent antibodies from triggering immune rejection of transplant cells
- Novel CAR T-Cell Therapy Displays Activity in Glioblastoma
- Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma
- Novel gene editing cell therapy shows curative potential in sickle cell disease
- NUS researchers develop breakthrough gene delivery technology for immune cells
- Off-the-shelf CAR-T produces complete remission in patient with advanced kidney cancer
- Oncolytic Virus/CAR T-Cell Therapy Combo Shows Preclinical Potential in Solid Tumors
- Ovarian cancer patients enrolled in first-in-human trial of CAR T cell therapy
- Partnership to develop gene editing therapies for neurological, muscular diseases
- PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | NEJM
- Penn analysis shows low risk of secondary cancers following CAR T cell therapy
- Penn study opens the door to let CAR T cells reach the tumor microenvironment
- Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors
- Post-translational covalent assembly of CAR and synNotch receptors for programmable antigen targeting | Nature Communications
- Potential treatment for glioblastoma multiforme
- Potentiating adoptive cell therapy using synthetic IL-9 receptors
- Precise DNA cleavage using CRISPR-SpRYgests | Nature Biotechnology
- Prime Editing Can Become the Future of Vision Loss Treatment
- Prime Editing Corrects Cystic Fibrosis Mutation
- Prime editing enables more precise correction of genetic problems than traditional CRISPR
- Prime- and base-editing mouse models advance cancer research
- Promising Data From First-Ever CRISPR Phage Therapy Trial
- Promising immunotherapy uses cancer-killing cells to destroy malignant tumors
- Radical lupus treatment uses CAR T-cell therapy developed for cancer
- Rapid manufacturing of non-activated potent CAR T cells | Nature Biomedical Engineering
- RASA2 ablation in T cells boosts antigen sensitivity and long-term function - Nature
- Real-World Analysis Evaluates Inpatient Vs Outpatient CAR T-Cell Therapy Administration in MCL and F
- Researchers develop 3D organoid model to advance understanding of gastroesophageal junction cancer
- Researchers develop new precision medicine technology for cancer immunotherapy
- Researchers develop tool to enhance NK cells against cancer
- Researchers take new approach to studying the development of the human brain
- Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia
- Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction
- Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial | Nature Medicine
- Scientists develop new immuno-therapeutic approach to target brain metastatic melanomas
- Self-copying RNA vaccine wins first full approval: what’s next? - Nature
- Simple method increases the efficacy of T cell therapy by cytokine conjugation
- Small and precise CRISPR-Cas13bt3 system can be used to shred viruses
- St. Jude scientists discover potential CAR T cell therapy target for brain and solid tumors
- ST3GAL1 and βII-spectrin pathways control CAR T cell migration to target tumors | Nature Immunology
- Study details the “immunometabolic editing” mechanism of tumor evolution
- Study focuses on new approach that delivers a "one-two punch" to help T cells attack solid tumors
- Study raises new hopes for blood cancer patients with an incomplete response to CAR T cell therapy
- T-knife - unleashing T-cell receptors on cancer - Nature
- Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases - Cell
- UCSF researchers hope to cure sickle cell disease through CRISPR gene editing
- Universal approach could potentially expand CAR T cell therapy to all blood cancers
- Universal CAR T Cell Therapy Helps Neat a Hard-to-Treat Pediatric Cancer
- Using synthetic gene circuits to better control the timing of immunotherapy
- UW researchers engineer stem cells that do not generate dangerous arrhythmias
- World-first therapy using donor cells sends autoimmune diseases into remission
- Yale researchers triple precision and efficiency in genome editing
News
- À Saclay, l’incubateur de pointe de Servier cherche à attirer les start-up @La Tribune
- Advances in vectorology and RNA delivery are opening a new chapter in vaccinology
- ANCHOR Technology / Partnership
- CAR-Based Immunotherapy
- European Society of Gene and Cell Therapy ESGCT 30th Annual Congress, Brussels
- GEG Tech and EPFL signed a collaborative research agreement
- GEG Tech and University Industry Foundation, Yonsei University Health System signed a collaborative research agreement
- GEG Tech announces the publication of a seminal RNA-BEV study on topical mRNA delivery in Communications Biology
- GEG-Tech Signs Distribution Agreement with Tebu-Bio
- Gene therapy: An Extensive Overview
- Innovation in cancerology: meeting in Monaco
- Innovative Nanoparticles for ex vivo and in vivo Genome Editing
- Innovative Nanoparticles to deliver mRNA for Vaccination
- ISCT 2023, Paris
- Preclinical and Personalized Breast Cancer Research
- Release of new mRNA vectors for prime & base editing
- Retinal gene therapy: Visual cycle restored in blind mice
- This incredible technique restores sight to blind mice… and soon to humans?
- We moved our Lab facility at Spartners by Servier and Biolabs
- World Vaccine Congress Europe, Barcelonna
Genome editing
- DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs
- Genetic Engineering: Evolution and Revolution
- Highly Efficient CRISPR/Cas9-Mediated Gene Editing
- Safer gene editing
- Sendai virus for CRISPR/Cas9 delivery
- The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes
Vectorology
- 3rd Generation Cocal Envelope Producer Cell Lines
- Erythropoietin expression in dividing cells
- Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles
- Live tracking of HIV-1 based lentiviral vectors
- Novel vesiculovirus envelope glycoproteins
- Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing
- Strain-promoted click reaction