Lenti-ONE Bcl-2 carries the cDNA of the B-cell CLL lymphoma 2 isoform alpha (sequence from human genome, NM_000633.2/CCDS 11981.1, 720 pb). This protein is an apoptosis regulating factor. By inhibiting the pro-apoptosis protein Bax, it promotes cellular survival.
Examples of Applications
- Use in vitro or in vivo to study apoptosis mechanisms
- Use in vitro, in vivo to study cancer mechanisms