Rapid Cohort Generation and Analysis of Disease Spectrum of Large Animal Model of Cone Dystrophy.
More than 60% efficiency in swine with GEG Tech vectors
Lenti-ONE GUCY2D
APPLICATIONS
- Angiogenesis
- Apoptosis, Oxidative Stress
- CAR T-cells
- CRISPR
- Differentiation
- Dominant Negative Mutants
- Neurology, Ophthalmology
- Optogenetics
- Recombinases, Editors
- Reporters and selection
- RNA Interference
TRANSGENES
Lenti-ONE GUCY2Dmut
DESCRIPTION
GUCY2Dmut cDNA encodes a mutant guanylate cyclase 2D with two substitutions: 837 D>E, 838 R>S (modified sequence from human genome, NM_000180.3, 3641 pb). This enzyme is guanylate cyclase 2D with dominant negative substitution D837E and R838S. These mutations have been associated in humans with cone dystrophies.
EXAMPLES OF APPLICATIONS
- Use in vitro or in vivo to study cone dystrophy
RESULTS
