Lenti-ONE BDNF

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Description

BDNF cDNA encodes the brain-derived neurotrophic factor isoform a (sequence from human genome, NM_001143805.1/CCDS7866.1, 744 pb). This neurotrophic factor may be used to promote neuronal survival in experimental gene therapy assays.

Igniting various cascades, BDNF can promote the transcription of survival factors through a Ras/MAPK/CREB pathway, and/or inhibit some death factors thanks to the P13K/AKT pathway.

Examples of Applications

• Use in vitro or in vivo to study nervous system
• Use in vitro or in vivo to study neurodegenerescence pathways and develop experimental therapy for neurodegenerative diseases

When pseudotyped with a Mokola envelope, Lenti-ONE BDNF limits transduction to glial cells. It can be useful to overexpress BDNF in glial cells around damaged neurons.

INFLUENCE OF PSEUDOTYPING ON THE TROPISM OF LENTI-ONE VECTORS