lenti-bdnf

Lenti-ONE BDNF

From €290.00

Description

BDNF cDNA encodes the brain-derived neurotrophic factor isoform a (sequence from human genome, NM_001143805.1/CCDS7866.1, 744 pb). This neurotrophic factor may be used to promote neuronal survival in experimental gene therapy assays.

BDNF signaling pathway

Igniting various cascades, BDNF can promote the transcription of survival factors through a Ras/MAPK/CREB pathway, and/or inhibit some death factors thanks to the P13K/AKT pathway.

Examples of Applications

  • Use in vitro or in vivo to study nervous system
  • Use in vitro or in vivo to study neurodegenerescence pathways and develop experimental therapy for neurodegenerative diseases

When pseudotyped with a Mokola envelope, Lenti-ONE BDNF limits transduction to glial cells. It can be useful to overexpress BDNF in glial cells around damaged neurons.

INFLUENCE OF PSEUDOTYPING ON THE TROPISM OF LENTI-ONE VECTORS

mokola envelope

GFP expression in murine and primate brain after stereotactic injection of Lenti-ONE PGK GFP. GFAP labeling shows glial cells, NeuN labeling shows neurons.