Lenti-ONE VEGF121

APPLICATIONS

  • Angiogenesis
  • Apoptosis, Oxidative Stress
  • CAR T-cells
  • CRISPR
  • Differentiation
  • Dominant Negative Mutants
  • Neurology, Ophthalmology
  • Optogenetics
  • Recombinases, Editors
  • Reporters and selection
  • RNA Interference

TRANSGENES

Lenti-ONE VEGF121

Lenti-ONE VEGF121 carries the VEGF121 cDNA. It encodes the vascular endothelial growth factor 121 (sequence from human genome, AF214570.1, 444 pb). This protein is a growth factor. It favors angiogenesis. It may also promote neuronal survival in experimental gene transfer assays.

Lenti-ONE GFP

DESCRIPTION

VEGF121 SIGNALING PATHWAY IN ENDOTHELIAL CELLS

 

Lenti-ONE VEGF121 -

EXAMPLES OF APPLICATIONS

  • Use with flt1 promoter to target the expression in endothelial cells

  • Use in vitro or in vivo to induce angiogenesis

  • Use in vitro, in vivo to study cancer mechanisms

RESULTS

VEGF EXPRESSION IN VITRO USING NON-INTEGRATIVE LENTI-ONE

 
Lenti-ONE VEGF121 -

Transduction of 293T cells in vitro with non-integrative Lenti-ONE VEGF121, VEGF165 or VEGF165b (100ng p24) induces transgene expression and VEGF secretion in cell culture medium (measured by ELISA).

Results provided by GEG Tech R&D