Genome editor-based gene therapy
Transient delivery of complex editing systems.
Technology
Biologically Engineered Vector Platforms
Engineering biology for advanced delivery
GEG Tech develops Biologically Engineered Vectors (BEVs) for the delivery of biological information.
Beyond viral / non-viral
The traditional viral / non-viral distinction no longer fully captures the diversity of emerging vector technologies. The BEV framework reflects this more complex and evolving landscape.
Within this framework, GEG Tech has developed three proprietary platforms:
Among them, RNA-ONE is our flagship platform for in vivo applications.
RNA-ONE
GEG Tech’s RNA-BEV platform
RNA-ONE is a Biologically Engineered Vector designed for transient RNA delivery.
The platform combines biological particle assembly with functional RNA delivery to generate strong but temporary biological activity.
This makes RNA-ONE particularly suited to applications where the biological effect may be durable while the delivered instruction only needs to be transient.
Designed for
Cancer immunotherapy
In vivo delivery of immune-programming instructions.
Vaccination
Transient antigen expression and immune stimulation.
Regenerative medicine
Localized delivery of RNA encoding regenerative factors.
Biological discovery
Transient perturbation of biological systems to explore function and mechanism.
From viral vectorology to RNA delivery
RNA-ONE originates from expertise developed through lentiviral vector engineering, but has been redesigned around a different function:
transient delivery of RNA rather than stable gene transfer.
The platform retains selected biological advantages of particle assembly and cellular entry while removing the requirement for conventional persistent genetic expression.
In its standard RNA-delivery configuration, RNA-ONE is not considered a GMO under the framework described by the French authority responsible for contained GMO use, subject to the nature of the transferred RNA.
This evolution illustrates the principle behind GEG Tech BEVs:
engineering biological systems around the function that needs to be delivered.
A versatile in vivo platform
RNA-ONE is designed around four core attributes:
Transient expression
Biological activity without persistent gene expression.
Complex payloads
Delivery of large and sophisticated RNA-encoded functions.
Biological assembly
Particles generated through engineered biological systems.
Programmable applications
A common platform adaptable to different payloads and biological objectives.
Complementary BEV platforms
RNA-ONE is the main GEG Tech platform for transient in vivo delivery.
GEG Tech also develops complementary BEV technologies for other delivery needs.
DNA-ONE
For durable or transient expression
DNA-ONE is designed for applications requiring transient, sustained and long term genetic function.
VLP-ONE
For transient biological delivery
VLP-ONE uses biologically assembled particles to deliver functional biological payloads without conventional stable gene transfer.
One vectorology platform. Different biological needs.
RNA-ONETransient RNA information
DNA-ONEDurable genetic information
VLP-ONETransient biological function
The appropriate vector depends on the biological question.
What needs to be delivered? To which cells? For how long?
Engineering vectors to understand, program and repair biology.
Explore RNA-ONEExplore ApplicationsCollaborate with GEG Tech