The landscape of cancer research is being transformed by the introduction of new mouse models using prime- and base-editing techniques. The prime-editing mouse model stands out for its high editing efficiencies, particularly in lung and pancreatic organoids. This model facilitates in-depth exploration of drug-resistance mutations, a critical aspect in cancer treatment. Similarly, the base-editing model demonstrates its prowess in creating high-throughput organoid-based models for studying complex genetic variations. The precision and efficiency of these models are crucial to understanding the mechanisms of cancer development and spread, and to identifying potential therapeutic targets. These advances mark a new era in cancer research, where understanding the genetic underpinnings of cancer is becoming more accessible and actionable.