Application Areas

Regenerative Beauty

GEG Tech’s RNA-BEV platform for localized skin programming

RNA-ONE is GEG Tech’s proprietary RNA-BEV technology for transient delivery of functional RNA.

For regenerative beauty applications, the platform brings together three characteristics:

Topical delivery

RNA-ONE can deliver functional RNA through the skin surface and induce expression within the epidermal compartment.

Transient expression

The biological instruction is temporary by design, allowing a controlled window of activity without permanent genetic modification.

Programmable cargo

The RNA payload can be adapted to encode different biological factors according to the desired effect on skin biology.

Together, these properties create the possibility of localized, transient and programmable intervention in healthy skin.

A technology already validated in skin

The technological foundation for regenerative beauty does not start from scratch.

GEG Tech has already demonstrated RNA-ONE-mediated RNA delivery across multiple skin models.

Following topical administration, RNA-ONE penetrates the epidermal layers and generates transient expression within the epidermal compartment.

This was demonstrated in reconstructed human epidermis and published in Communications Biology in 2026 -

RNA-ONE has also been evaluated with FGF7 mRNA across cellular, reconstructed tissue and in vivo regenerative models.

These studies demonstrate that the platform can:

deliver functional RNA topically,

reach epidermal cells,

generate transient local protein expression,

and produce a measurable biological response in skin tissue.

They provide the technological foundation from which cosmetic-specific programs can now be developed.

From regenerative dermatology to regenerative beauty

Regenerative dermatology and regenerative beauty address the same organ but different biological objectives.

In dermatology, the objective may be to restore damaged or pathological tissue.

In regenerative beauty, the focus shifts toward healthy skin and the transient modulation of biological pathways associated with tissue maintenance, renewal and appearance.

The delivery challenge, however, remains closely related.

Can an RNA instruction reach the appropriate skin compartment?

Can it produce sufficient local activity?

Can expression remain temporary?

Can systemic exposure be limited?

RNA-ONE has already generated preclinical evidence addressing these fundamental questions.

The next step is to translate this delivery capability toward cosmetic-specific biological targets and endpoints.

Local action by design

For regenerative beauty, localization is particularly important.

Following topical administration, RNA-ONE activity remains primarily associated with the treated epidermal compartment.

The platform therefore offers the possibility of generating biological activity where it is intended to act, while limiting unnecessary systemic exposure.

Combined with transient expression, this creates two particularly relevant dimensions for cosmetic applications:

Local by delivery. Temporary by design.

This distinction is fundamental when the objective is to influence healthy skin without creating permanent biological modification.

A non-GMO RNA delivery platform

RNA-ONE also differs fundamentally from conventional stable gene-transfer technologies.

In its standard RNA-delivery configuration, the RNA-ONE architecture was reviewed by the French authority responsible for contained GMO use.

For the configuration described, particles transferring coding or non-coding RNA were considered not to be GMOs and not to generate GMOs, provided that the RNA does not encode a replicative viral genome, reverse-transcriptase activity capable of generating DNA, or a genome-editing system.

For regenerative beauty applications based on transient expression of conventional RNA cargos, this distinction reinforces the positioning of RNA-ONE as a biologically engineered delivery technology rather than a permanent genetic intervention.

From platform validation to cosmetic programs

RNA-ONE has already moved beyond the stage of exploratory skin delivery.

The platform has been:

validated in keratinocytes,

demonstrated in reconstructed human epidermis,

shown to deliver functional RNA topically,

shown to generate transient epidermal expression,

evaluated in vivo in skin-regeneration models,

and published in a peer-reviewed journal.

This provides an existing technology base from which GEG Tech and partners can develop regenerative beauty programs focused on healthy skin.

Development can begin from a biological target, candidate factor or desired skin function and focus on adapting the RNA cargo, formulation, exposure conditions and application protocol.

Technology maturity

RNA-ONE | Regenerative Beauty
Development milestone	Status
Functional RNA delivery in keratinocytes	Demonstrated
Topical RNA delivery	Demonstrated
Reconstructed human epidermis	Demonstrated
Epidermal penetration	Demonstrated
Transient epidermal expression	Demonstrated
Localized biological activity	Demonstrated preclinically
In vivo skin activity	Demonstrated preclinically
Peer-reviewed skin publication	Published
Standard RNA-ONE non-GMO status	Established for the reviewed configuration
Cosmetic-specific biological programs	Available for partner development
Cosmetic-specific safety / translation	Development pathway established

A development platform for beauty partners

GEG Tech operates through a collaborative studio-lab model.

For regenerative beauty programs, collaboration can start from a partner’s biological hypothesis, ingredient concept or desired skin function.

Development can include:

Target selection

Identification of biological pathways compatible with transient RNA programming.

RNA cargo design

Selection and engineering of the corresponding biological instruction.

Vector and formulation adaptation

Optimization of topical delivery and epidermal exposure.

Skin-model evaluation

Testing in relevant cellular and reconstructed human skin systems.

Preclinical and safety development

Progressive characterization of biological activity, local exposure and product-specific safety.

The objective is to allow beauty and skincare partners to explore RNA-based regenerative concepts using an existing skin-validated delivery platform.

Evidence & milestones

Scientific evidence

Biologically engineered vectors enable topical mRNA delivery for skin regeneration

Communications Biology — 2026

The study demonstrated topical delivery of functional mRNA, transient expression within reconstructed human epidermis and biological activity of RNA-ONE-mediated FGF7 delivery in regenerative skin models.

Read the publication

Technology milestone

Topical RNA delivery established in human skin models

RNA-ONE demonstrated that biologically engineered particles can deliver functional RNA through topical administration and generate localized, transient expression within the epidermis.

Regenerative Beauty program

GEG Tech is applying this skin-delivery foundation to the development of RNA-based approaches specifically designed for healthy skin and regenerative beauty applications.

Discuss a Regenerative Beauty Program

Toward programmable skincare

The next generation of beauty technologies may increasingly act not only by supplying active ingredients, but by temporarily instructing skin biology itself.

RNA provides a way to do this without requiring persistent expression.

RNA-ONE provides the delivery platform.

Local delivery. Transient programming. Regenerative biology.

An existing skin-validated platform ready to support the next generation of regenerative beauty programs.

Discuss a regenerative beauty program Explore RNA-ONE All application areas