These past few months, cancer immunotherapy has sped-up thanks to CAR technology. One look at the recent news about this is enough to figure that out. As examples: Two major deals between pharmaceutical companies and biotechs specialized in CAR T-cells: Gilead bought Kite Pharma for $12 billion, and Celgene bought Juno Therapeutics…
ANCHOR Technology / Partnership We are proud to annonce you that GEG Tech has validated the combination of the ANCHOR technology developed by NeoVirTech with our Lenti-ONE vectors. This breakthrough technology allowed us to generate the first auto-fluorescent lentiviral vectors for live imaging and screening applications. For more details about the new possibilities offered by…
First-ever live tracking of HIV-1 based lentiviral vectors in human cells Technology breakthrough: visualization of lentivirus genomes in living cells using ANCHOR technology. We are proud to announce that we obtain great results through a collaborative project with NeoVirTech, a company developing auto fluorescent virus for imaging and screening applications….
The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes In this article, Merienne et al. designed a smart lentiviral vector system to improve the safety for genome editing of CNS disease gene. They characterized their CRISPR self-inactivating system (KamiCas9) for permanent disruption of huntingtin gene in the context…
Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal and…
Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing The CRISPR/Cas9 systems have revolutionized the field of genome editing by providing unprecedented control over gene sequences and gene expression in many species, including humans. Lentiviral vectors (LVs) are an important means of delivering CRISPR/Cas9 components due…
Preclinical and Personalized Breast Cancer Research As scientists involved in life science research, we would like to let you know about the research project on breast cancer, led by the Brisken Lab in EPFL, Switzerland. The scientific team of GEG Tech is proud to be a part of it, designing…
Episomal lentiviral vectors confer erythropoietin expression in dividing cells Lentiviral vectors have evolved over the last decade as powerful and reliable gene transfer tools for dividing and non-dividing cells because they possess a large packaging capacity, weak immunogenesis, and a high flexible of design. However, in some cases, the integrating…
Genetic Engineering: Evolution and Revolution Over the last years, new genetic engineering technologies have emerged and undoubtedly show up game-changing. Genome engineering is since a long time explored and used because there is a lot at stake here in many fields. Indeed, the possibility to add, remove or change precisely…
Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing A significant recent advance in genome engineering is the development of the CRISPR/Cas9 system for nuclease based genome editing. However, several cell types are not easily transfected and in vivo delivery of the…
