Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations
The CRISPR-Cas9 molecular complex is the tool most widely used by scientists around the world. It cuts double-stranded DNA at the exact point where the genetic material is to be modified. The cut activates two natural repair mechanisms, including homology-directed repair. To induce the cell to use this repair, researchers have recently begun using a […]