Simple method increases the efficacy of T cell therapy by cytokine conjugation
T-cell transfer therapies have not yet been successfully applied to solid tumors because T cells do not readily penetrate and persist in solid tumor masses for long periods of time, and because their activity is attenuated by an immunosuppressive tumor microenvironment. One way to overcome these limitations could be to couple T cell transfer therapies […]
CAR-T-cell Shows Promise in Patients With Lymphoma of the Brain and Spinal Cord in Early Trial
Lymphomas can begin in the brain or spinal cord, or tumors can spread to these sites after originating in other parts of the body. Researchers knew that CAR-T cells could access the brain from previous research, but the neurological toxicities that can occur during treatment raised concerns about deploying the therapy against central nervous system […]