Nonviral CAR-T is ‘remarkably safe’ and clinically active in B-cell ALL

Nonviral CAR-T is ‘remarkably safe’ and clinically active in B-cell ALL - Blog

CARCIK-CD19, an investigational therapy developed by scientists in Italy, involves donor-derived CD19-targeted CAR T cells differentiated according to the cytokine-induced killer (CIK) cell protocol that uses non-viral Sleeping Beauty transposon gene transfer to prevent graft-versus-host disease. More than 60% of patients with relapsed or refractory B-cell acute lymphoblastic leukemia achieved initial complete remission after receiving […]

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics | Nature Neuroscience

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics | Nature Neuroscience - Blog

The mammalian brain contains many specialized cells that develop from a thin sheet of neuroepithelial progenitor cells. However, the lineage relationships between mature cell types and progenitor cells are not well understood. Therefore, researchers performed high-throughput clonal tracking and expression profiling of mouse forebrain cells using single-cell and spatial transcriptomics and found two populations of […]