Decade-long leukaemia remissions with persistence of CD4+ CAR T cells – Nature

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells - Nature - Blog

The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers1–7. However, little is known about the long-term potential and clonal stability of the infused cells. Here we studied long-lasting CD19-redirected chimeric antigen receptor (CAR) T cells in two patients with chronic lymphocytic leukaemia1–4 who achieved a […]