T-knife – unleashing T-cell receptors on cancer – Nature

T-knife - unleashing T-cell receptors on cancer - Nature - Blog, Cancer immunotherapy

For 17 years, Thomas Blankenstein has been working on his Berlin-based start-up T-knife and is finally going to be able to test his T-cell receptor (TCR) cancer immunotherapy. To make this immunotherapy, they replaced the TCR genes of a mouse with those of a human and inserted genes to encompass both the human TCR repertoire […]