Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis | Nature Biotechnology
The accumulation of fat in the liver is an increasingly common disease worldwide, with more than a quarter of the world’s population affected. Various causes can lead to the development of fatty liver, with diet and lifestyle being the most common contributors. There is currently no treatment for fatty liver that can stop or reverse […]
Liquid biopsy predicts response to CAR-T for multiple myeloma
Multiple myeloma is difficult to treat because of the heterogeneity of genomic aberrations and responses to treatment. Currently, bone marrow examinations are used for genomic evaluation at diagnosis, at evaluation of minimal residual disease and at relapse. This is an invasive procedure, but it also carries the risk of false negatives due to spatial heterogeneity. […]
Bispecific LV20.19 CAR T Cells Induce 92% CR Rate in Relapsed/Refractory Mantle Cell Lymphoma
Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy that researchers believe is not curable using current standard approaches. However, researchers developed a bispecific CAR T-cell therapy targeting both CD20 and CD19 cells induced a 92% complete response (CR) rate at 90 days in patients with relapsed/refractory MCL. In the study, researchers administered CAR T […]
New type of immunotherapy effective in mice with ovarian cancer
Many ovarian tumors contain mesothelin. Researchers wanted to test three types of CAR molecules programmed to attack this particular protein. They repeatedly exposed ovarian cancer cells to CAR T cells in test tubes and conducted several experiments in mice. All three types of CAR T cells significantly prolonged the lives of the mice with cancer […]
Improving CAR-based-immunotherapies using a molecular anchor
CAR T cells have shown some success in the clinic in treating certain cancers, such as relapsed leukemia. However, CAR T cells have not been successful in delivering solid tumors, in part because of problems with immune cell activation. Adding a molecular anchor to the key protein used to recognize cancer in cellular immunotherapies can […]
Simple method increases the efficacy of T cell therapy by cytokine conjugation
T-cell transfer therapies have not yet been successfully applied to solid tumors because T cells do not readily penetrate and persist in solid tumor masses for long periods of time, and because their activity is attenuated by an immunosuppressive tumor microenvironment. One way to overcome these limitations could be to couple T cell transfer therapies […]
CAR-T-cell Shows Promise in Patients With Lymphoma of the Brain and Spinal Cord in Early Trial
Lymphomas can begin in the brain or spinal cord, or tumors can spread to these sites after originating in other parts of the body. Researchers knew that CAR-T cells could access the brain from previous research, but the neurological toxicities that can occur during treatment raised concerns about deploying the therapy against central nervous system […]
Simple method increases the efficacy of T cell therapy by cytokine conjugation
T-cell transfer therapies have not yet been successfully applied to solid tumors because T cells do not readily penetrate and persist in solid tumor masses for long periods of time, and because their activity is attenuated by an immunosuppressive tumor microenvironment. One way to overcome these limitations could be to couple T cell transfer therapies […]
CAR T cell therapy may enhance the effectiveness of surgery for solid tumors
Surgery can be curative when a solid tumor cancer has not spread. However, it is often very difficult for surgeons to discern where a tumor ends and healthy tissue begins. Thus, for many types of cancer, post-surgical recurrence due to remaining microscopic tumor cells is common. One possible approach to this problem is to apply […]
Study details the “immunometabolic editing” mechanism of tumor evolution
The immune system can induce metabolic adaptations in tumor cells at an early stage that promote their growth. Researchers identify three proteins that orchestrate this effect: IFNγ, STAT3 and c-Myc. The researchers show that IFNγ activates, in addition to the STAT1-mediated signaling pathway, the STAT3-mediated pathway. This pathway alters the genome expression patterns of the […]