Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction
Cellular senescence is an irreversible cell cycle arrest induced in response to stress. Under stressful conditions, matrix remodeling enzymes and pro-inflammatory cytokines are produced, termed Senescence-Associated Secretory Phenotype (SASP). In young individuals with physiological conditions, such as tumor suppression and wound healing, SASP facilitates the recruitment of immune cells, which facilitate tissue restoration and the […]