CRISPR-Based Anti-CD19 CAR T-Cell Therapy Is Safe and Effective in Relapsed/Refractory NHL
The CD19-directed, non-viral, PD-1 locus-specific, CRISPR-based integrated CAR T cell therapy BRL-201 was associated with a manageable safety profile and elicited early indications of efficacy in patients with relapsed and refractory non-Hodgkin’s lymphoma (NHL), according to results from a first-in-man Phase 1 trial (NCT04213469). No dose-limiting toxicity (DLT) was observed in any of the patient […]